Scientific Framework

Research and Development Philosophy and Guiding Principles

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Research and Development Philosophy and Guiding Principles

This document sets out Advalife Science's research and development philosophy, the principles that guide scientific judgement, and its approach to translation from research into medicine development. Viewing life as a complex system, it sets out how research hypotheses and evidence are handled, the place of scientific validation and reproducibility, and the principles that connect intellectual property, non-clinical research, manufacturing, CMC and clinical development.

This document sets out a research and development philosophy and scientific framework. It does not recommend any particular treatment or guarantee the efficacy, safety, regulatory approval or commercialisation of any individual development candidate.

Document: English | 18 pages
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Scientific Framework

Research and Development Philosophy and Guiding Principles — 18 pages

Research and Development Philosophy, page 1: CoverResearch and Development Philosophy, page 2: Section 00  Executive StatementResearch and Development Philosophy, page 3: Section 02  The Central PropositionResearch and Development Philosophy, page 4: Section 04  Investigating Biological ComplexityResearch and Development Philosophy, page 5: Section 06  Human-origin signalResearch and Development Philosophy, page 6: Section 08  Evidence PrinciplesResearch and Development Philosophy, page 7: Section 09  Evidence ArchitectureResearch and Development Philosophy, page 8: Section 10  From Clinical Observation to Scientific AssetResearch and Development Philosophy, page 9: Section 12  Translational Learning LoopResearch and Development Philosophy, page 10: Section 14  Intellectual PropertyResearch and Development Philosophy, page 11: Section 16  Manufacturing and CMCResearch and Development Philosophy, page 12: Section 18  The Organisation as a Translational PathwayResearch and Development Philosophy, page 13: Section 19  An Integrated Platform for Medicine DevelopmentResearch and Development Philosophy, page 14: Section 20  The Significance of the First MedicineResearch and Development Philosophy, page 15: Section 21  Platform Value Depends on ReproducibilityResearch and Development Philosophy, page 16: Section 23  Respecting Scientific, Ethical and Legal BoundariesResearch and Development Philosophy, page 17: Section 25  Key TermsResearch and Development Philosophy, page 18: Section 26  Key Terms (continued) and Source Basis

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SCIENCE & R&D